Platelet Rich Fibrin Matrix used for Rotator Cuff Tendon Healing |
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Another interesting
article regarding the use of PRFM (platelet Rich Fibrin Matrix) on rotator cuff
tendon healing. This study shows that there is no effect, and possibly a
negative effect, on the rate of recovery post surgery. Something to consider
for those considering surgery of the rotator cuff. At our chiropractic office in
Fairfax, we employ multiple techniques of Pre-reb, or rehab before the surgery,
designed to reduce recovery time after the surgery is performed.
The Effect of Platelet-Rich Fibrin Matrix on Rotator Cuff Tendon Healing: A Prospective, Randomized Clinical Study
by Rodeo, S. A., Delos, D., Williams, R. J.,
Adler, R. S., Pearle, A., Warren, R. F.
Background: There is a strong need for methods to improve the biological
potential of rotator cuff tendon healing. Platelet-rich fibrin matrix (PRFM)
allows delivery of autologous cytokines to healing tissue, and limited evidence
suggests a positive effect of platelet-rich plasma on tendon biology.
Purpose: To evaluate the effect of platelet-rich fibrin matrix on
rotator cuff tendon healing.
Study Design: Randomized controlled trial; Level of evidence, 2.
Methods: Seventy-nine patients undergoing arthroscopic rotator cuff
tendon repair were randomized intraoperatively to either receive PRFM at the
tendon-bone interface (n = 40) or standard repair with no PRFM (n = 39).
Standardized repair techniques were used for all patients. The postoperative
rehabilitation protocol was the same in both groups. The primary outcome was
tendon healing evaluated by ultrasound (intact vs defect at repair site) at 6
and 12 weeks. Power Doppler ultrasound was also used to evaluate vascularity in
the peribursal, peritendinous, and musculotendinous and insertion site areas of
the tendon and bone anchor site. Secondary outcomes included standardized
shoulder outcome scales (American Shoulder and Elbow Surgeons [ASES] and
L’Insalata) and strength measurements using a handheld dynamometer. Patients
and the evaluator were blinded to treatment group. All patients were evaluated
at minimum 1-year follow-up. A logistic regression model was used to predict
outcome (healed vs defect) based on tear severity, repair type, treatment type
(PRFM or control), and platelet count.
Results: Overall, there were no differences in tendon-to-bone healing
between the PRFM and control groups. Complete tendon-to-bone healing (intact
repair) was found in 24 of 36 (67%) in the PRFM group and 25 of 31 (81%) in the
control group (P = .20). There were no significant differences in
healing by ultrasound between 6 and 12 weeks. There were gradual increases in
ASES and L’Insalata scores over time in both groups, but there were no
differences in scores between the groups. We also found no difference in
vascularity in the peribursal, peritendinous, and musculotendinous areas of the
tendon between groups. There were no differences in strength between groups.
Platelet count had no effect on healing. Logistic regression analysis demonstrated
that PRFM was a significant predictor (P = .037) for a tendon
defect at 12 weeks, with an odds ratio of 5.8.
Conclusion: Platelet-rich fibrin matrix applied to the tendon-bone
interface at the time of rotator cuff repair had no demonstrable effect on
tendon healing, tendon vascularity, manual muscle strength, or clinical rating
scales. In fact, the regression analysis suggests that PRFM may have a negative
effect on healing. Further study is required to evaluate the role of PRFM in
rotator cuff repair.
Joshua M. Brooks, D.C.
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ABC Clinics
Rosa Family Chiropractic
2750 Prosperity Ave, Suite
550
Fairfax, VA 22031
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